ABSTRACT Proteinase-activated receptors (PARs) function as cell sensors for proteinases. Expression of PARs in immune cells suggests a role in innate immunity. PAR1 mediates the cellular effects of thrombin and causes cytokine and chemokine production by endothelial cells and macrophages. Expression of PAR1 on fibroblasts mediates the profibrogenic activity of thrombin and triggers extracellular matrix protein deposition. PAR2 activation by trypsin, tryptase, and coagulation proteinases triggers both pro- and antiinflammatory activities by regulating monocyte recruitment/activation in inflamed tissues. Drug Dev. Res. 60:65–70, 2003.
Proteinase-Activated receptors (PARs) and immune function
FIORUCCI, Stefano;
2003
Abstract
ABSTRACT Proteinase-activated receptors (PARs) function as cell sensors for proteinases. Expression of PARs in immune cells suggests a role in innate immunity. PAR1 mediates the cellular effects of thrombin and causes cytokine and chemokine production by endothelial cells and macrophages. Expression of PAR1 on fibroblasts mediates the profibrogenic activity of thrombin and triggers extracellular matrix protein deposition. PAR2 activation by trypsin, tryptase, and coagulation proteinases triggers both pro- and antiinflammatory activities by regulating monocyte recruitment/activation in inflamed tissues. Drug Dev. Res. 60:65–70, 2003.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
