Plasma surface modification of porous PLLA films: Analysis of surface properties and in vitro hydrolytic degradation

The aim of this research was to investigate the effects of plasma treatment on the surface and on the in vitro degradation behavior of poly(L-lactide) (PLLA) films. Polymer films were prepared by solvent casting, and their surface was modified by radiofrequency plasma treatments by using oxygen and tetrafluorocarbon gas. Pristine and treated PLLA films were characterized by field emission and atomic force microscopy and by contact angle measurements. In vitro hydrolytic degradation studies were conducted by measurements of weight loss, water absorption, visual inspection, and thermal transitions as a function of the incubation time. As-deposited PLLA films show a uniform distribution of ring-like porous structures on the surface due to solvent evaporation. Plasma treatments produce a mass reduction following the etching of the polymer surface. Moreover, the morphology of the porous polymer is modified by the plasma, which induces different micro/nanometric topographic reliefs as a function of the different selected plasma processing parameters. The results indicate PLLA surface become hydrophilic and the surface roughness increased with treatment time in the case of oxygen, whereas a hydrophobic behavior was induced with tetrafluorocarbon plasma treatment. However, in vitro degradation studies show that plasma treatments do not affect the PLLA bulk and the hydrolytic degradation properties. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012