A new 2-steps synthesis of 2′-epi-Taxol starting from natural Taxol• is described. The approach is centred on the formation of oxazoline on the side chain with concomitant inversion of the C-2′ followed by acid hydrolysis.

A High Yield Semisynthetic Approach to 2’-epi-Taxol

CURINI, Massimo;MARCOTULLIO, Maria Carla;ROSATI, Ornelio
1996

Abstract

A new 2-steps synthesis of 2′-epi-Taxol starting from natural Taxol• is described. The approach is centred on the formation of oxazoline on the side chain with concomitant inversion of the C-2′ followed by acid hydrolysis.
1996
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/114072
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
social impact