In this communication it will be reported the formulation and the in vitro characterization of potentially respirable spray-dried microparticles (MP) loaded with PhSeZnCl, a novel compound with GPx-mimetic activity. PhSeZnCl was encapsulated in poly(D-Lactide) (PLA) polymer by spray-drying with a Buchi B290 spray-dryer. The MP were characterized in terms of size distribution and morphology and compared with the spray-dried powder without excipient. The PLA MP loaded with PhSeZnCl showed spherical regular shape and reduced dose and timedependent toxicity in iMEFS-KO cells compared to the free molecule and the spray-dried powder. Preliminary investigation by fluorescence microscopy and ICP-AES analysis showed partial internalization of the MP by cells. The MP also showed high loading and proper characteristics to be administered as a dry powder in the lungs.

PhSeZnCl a novel selenium compound with GPx-mimetic activity: formulation and in vitro characterization

PIRODDI, MARTA;GALLI, Francesco;SANTI, Claudio;GIOVAGNOLI, Stefano
2013

Abstract

In this communication it will be reported the formulation and the in vitro characterization of potentially respirable spray-dried microparticles (MP) loaded with PhSeZnCl, a novel compound with GPx-mimetic activity. PhSeZnCl was encapsulated in poly(D-Lactide) (PLA) polymer by spray-drying with a Buchi B290 spray-dryer. The MP were characterized in terms of size distribution and morphology and compared with the spray-dried powder without excipient. The PLA MP loaded with PhSeZnCl showed spherical regular shape and reduced dose and timedependent toxicity in iMEFS-KO cells compared to the free molecule and the spray-dried powder. Preliminary investigation by fluorescence microscopy and ICP-AES analysis showed partial internalization of the MP by cells. The MP also showed high loading and proper characteristics to be administered as a dry powder in the lungs.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1177677
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