Polymer-stabilized perylene nanoparticles were prepd. through a solvent exchange method. The formation of the nanostructures in aq. soln. was confirmed by the appearance of a red-shifted emission attributable to the formation of excimerlike aggregates. The behavior of org. nanostructures in the presence of lipid vesicles was investigated through steadystate and time-resolved fluorescence measurements. When no further surface treatment is applied to the nanoparticles, changes in the decay times and emission spectra demonstrate that inside the lipid bilayers the nanoparticles redissolve into the monomeric form with a rate and efficiency detd. by the working temp. (above and below the transition temp. Tm of the phospholipid). On the other hand, when the stabilized shell is UV-cured to induce photo-crosslinking of the polymeric chains, the nanoparticle stability increases and their redissoln. in the membrane is prevented. Confocal fluorescence images support the data obtained in bulk. The results indicate that the prepd. nanostructures could be successfully used either as nanometric carriers for the delivery of poor water-sol. lipophilic compds. or as imaging tools depending on the rigidity/crosslinking degree of their polymeric stabilizer shell.

Driving the Interactions between Organic Nanoparticles and Phospolipidic Membranes by an Easy Treatment of the Surface Stabilizer

TARPANI, LUIGI;LATTERINI, Loredana
2013

Abstract

Polymer-stabilized perylene nanoparticles were prepd. through a solvent exchange method. The formation of the nanostructures in aq. soln. was confirmed by the appearance of a red-shifted emission attributable to the formation of excimerlike aggregates. The behavior of org. nanostructures in the presence of lipid vesicles was investigated through steadystate and time-resolved fluorescence measurements. When no further surface treatment is applied to the nanoparticles, changes in the decay times and emission spectra demonstrate that inside the lipid bilayers the nanoparticles redissolve into the monomeric form with a rate and efficiency detd. by the working temp. (above and below the transition temp. Tm of the phospholipid). On the other hand, when the stabilized shell is UV-cured to induce photo-crosslinking of the polymeric chains, the nanoparticle stability increases and their redissoln. in the membrane is prevented. Confocal fluorescence images support the data obtained in bulk. The results indicate that the prepd. nanostructures could be successfully used either as nanometric carriers for the delivery of poor water-sol. lipophilic compds. or as imaging tools depending on the rigidity/crosslinking degree of their polymeric stabilizer shell.
2013
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1193679
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