Aim. The aim of this study was to investigate the relationship between 2-deoxy-2[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI) with apparent diffusion coefficients (ADC) in brain tumors. Methods. Fifteen patients with 18 metastatic brain lesions underwent gadolinium-enhanced fast spoiled gradient echo (Gd-FSPGR), DWI with ADC maps, and [18F]FDG PET. Spherical three-dimensional tumor and contralateral control regions of interest (ROIs) were drawn on Gd-FSPGR, ADC and PET images, Gd-FSPGR being the target for statistical parametric mapping with realigned ADC and PET to calculate ROI ratios; linear regression analysis was performed. Results. An inverse correlation (r2=0.2746, P=0.0256) was found between PET and ADC ratios; plotting ratios: when PET ratios were high, ADC ratios were low, while, when ADC ratios were high, PET ratios were low. Conclusion. Our preliminary data suggest an inverse relationship between PET and ADC indices. Hypercellular areas could increase impedance to water diffusion, resulting in low ADC values and high [18F]FDG uptake, while lower cellularity areas show increased ADC with decreased [18F]FDG uptake.
Relationship between PET-FDG and MRI apparent diffusion coefficients in brain tumors
PALUMBO, Barbara;
2009
Abstract
Aim. The aim of this study was to investigate the relationship between 2-deoxy-2[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI) with apparent diffusion coefficients (ADC) in brain tumors. Methods. Fifteen patients with 18 metastatic brain lesions underwent gadolinium-enhanced fast spoiled gradient echo (Gd-FSPGR), DWI with ADC maps, and [18F]FDG PET. Spherical three-dimensional tumor and contralateral control regions of interest (ROIs) were drawn on Gd-FSPGR, ADC and PET images, Gd-FSPGR being the target for statistical parametric mapping with realigned ADC and PET to calculate ROI ratios; linear regression analysis was performed. Results. An inverse correlation (r2=0.2746, P=0.0256) was found between PET and ADC ratios; plotting ratios: when PET ratios were high, ADC ratios were low, while, when ADC ratios were high, PET ratios were low. Conclusion. Our preliminary data suggest an inverse relationship between PET and ADC indices. Hypercellular areas could increase impedance to water diffusion, resulting in low ADC values and high [18F]FDG uptake, while lower cellularity areas show increased ADC with decreased [18F]FDG uptake.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
