J Med Vet Mycol. 1996 Jun-Jul;34(3):219-22. Candida albicans stress mannoprotein, SMP200, enhances tumour necrosis factor secretion in the murine macrophage cell line ANA-1. Pitzurra L, Polonelli L, Cantelli C, Gerloni M, Ponton J, Bikandi J, Blasi E. SourceDepartment of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy. Abstract Tumour necrosis factor (TNF) secretory activity has been studied in the murine macrophage cell line ANA-1 following in vitro exposure to Candida albicans 200 kDa stress mannoprotein (SMP200). Treatment of ANA-1 murine macrophages with 200 kDa stress mannoprotein results in increased TNF secretion. The phenomenon is (i) dose- and time-dependent, (ii) abrogated by 200 kDa stress mannoprotein preincubation with a specific monoclonal antibody, and (iii) dependent on intact murine macrophage Ca2+/calmodulin-dependent protein kinase function. PMID: 8803805

Candida albicans stress mannoprotein, SMP200, enhances tumor necrosis factor secretion in the murine macrophage cell line ANA-1.

PITZURRA, Lucia;
1996

Abstract

J Med Vet Mycol. 1996 Jun-Jul;34(3):219-22. Candida albicans stress mannoprotein, SMP200, enhances tumour necrosis factor secretion in the murine macrophage cell line ANA-1. Pitzurra L, Polonelli L, Cantelli C, Gerloni M, Ponton J, Bikandi J, Blasi E. SourceDepartment of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy. Abstract Tumour necrosis factor (TNF) secretory activity has been studied in the murine macrophage cell line ANA-1 following in vitro exposure to Candida albicans 200 kDa stress mannoprotein (SMP200). Treatment of ANA-1 murine macrophages with 200 kDa stress mannoprotein results in increased TNF secretion. The phenomenon is (i) dose- and time-dependent, (ii) abrogated by 200 kDa stress mannoprotein preincubation with a specific monoclonal antibody, and (iii) dependent on intact murine macrophage Ca2+/calmodulin-dependent protein kinase function. PMID: 8803805
1996
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/120831
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