Anti-inflammatory drugs with aryl-propionic structure showed plasticizing effect on different polymers, causing problems during manufacturing of polymeric devices. For example, during the preparation of polymer microparticles, the presence of a plasticizing drug can hinder the recovery of microparticles, especially when polymers with low molecular weight are employed. To reduce plasticization of polyesters, the anti-inflammatory drug ketoprofen (K) was included in hydrotalcite (HTlc) and encapsulated in polylactide (PLA) and poly(lactide-co-glycolide) (PLGA), obtaining composite microparticles.

Avoiding ketoprofen plasticization during microparticle manufacturing: the case of hydrotalcite

CASAGRANDE, SERENA;CASSETTI, EMANUELE;SCHOUBBEN, Aurelie Marie Madeleine;GIOVAGNOLI, Stefano;BLASI, PAOLO;RICCI, Maurizio
2014

Abstract

Anti-inflammatory drugs with aryl-propionic structure showed plasticizing effect on different polymers, causing problems during manufacturing of polymeric devices. For example, during the preparation of polymer microparticles, the presence of a plasticizing drug can hinder the recovery of microparticles, especially when polymers with low molecular weight are employed. To reduce plasticization of polyesters, the anti-inflammatory drug ketoprofen (K) was included in hydrotalcite (HTlc) and encapsulated in polylactide (PLA) and poly(lactide-co-glycolide) (PLGA), obtaining composite microparticles.
2014
9788890854415
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1219684
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