Leptin is a polypeptide secreted by adipose tissue regulating appetite and energy consumption. It acts by binding with a specific receptor that is expressed in various tissues suggesting that leptin might exert diverse biological functions other than energy metabolism. Accordingly, leptin acts as a mitogen for a growing number of cell types, including the epidermis where it was detected together with its receptor. In particular, leptin strongly stimulate a proliferative response of keratinocytes during skin repair. Moreover, leptin and its receptor were detected in hair follicle where it may be involved in the control of hair follicle morphogenesis. At present, this hormone is considered a novel therapeutic factor to improve severely disturbed wound-healing conditions. To evaluate the action of leptin in the skin of the dog, we investigated the presence and localization of leptin receptor by using immunohistochemical technique. Through the application of a polyclonal antibody, we observed the expression of the receptor in the cells of the basal layer of the epidermis, in the hair follicles and in the apical membrane of the apocrine sweat gland cells. As regards hair follicles, the positivity was observed in the cells of the outer root sheath both in growing and regressive phase. The identification of leptin receptor suggests an important role of leptin in the metabolism of the epidermis and skin structures in canine species.

Leptin receptor identification in canine skin

MERCATI, FRANCESCA;PASCUCCI, Luisa;
2014

Abstract

Leptin is a polypeptide secreted by adipose tissue regulating appetite and energy consumption. It acts by binding with a specific receptor that is expressed in various tissues suggesting that leptin might exert diverse biological functions other than energy metabolism. Accordingly, leptin acts as a mitogen for a growing number of cell types, including the epidermis where it was detected together with its receptor. In particular, leptin strongly stimulate a proliferative response of keratinocytes during skin repair. Moreover, leptin and its receptor were detected in hair follicle where it may be involved in the control of hair follicle morphogenesis. At present, this hormone is considered a novel therapeutic factor to improve severely disturbed wound-healing conditions. To evaluate the action of leptin in the skin of the dog, we investigated the presence and localization of leptin receptor by using immunohistochemical technique. Through the application of a polyclonal antibody, we observed the expression of the receptor in the cells of the basal layer of the epidermis, in the hair follicles and in the apical membrane of the apocrine sweat gland cells. As regards hair follicles, the positivity was observed in the cells of the outer root sheath both in growing and regressive phase. The identification of leptin receptor suggests an important role of leptin in the metabolism of the epidermis and skin structures in canine species.
2014
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1219903
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