Objective: To assess the predictivity of predefined variables with respect to long-term mortality in a cohort of patients with chronic critical leg ischaemia (CLI). Design" Prospective observational study. Methods: Census offices were asked to release information on survival or death status of 574 patients with CLI 2 years after their recruitment in the study. Results: 0f522 patients with available information, 165 (31.6%) died within 2 years of hospitaI admission, mostlyfrom vascular causes as expected. Among the variables considered, male sex, current smoking, arterial hypertension, diabetes metlitus, hypercholesterolaemia, obesity, history of myocardial infarction and low ankle systolic pressure showed no univariate association with mortality. The multivariate analysis also excluded revascularisation procedures and the Fontaine stage as prognostic factors in terms of mortality. Besides age >_70 years (relative risk, RR 1.94; 95% confidence interval (CI) 1.37-2.70), only a history of stroke (RR 1.82; 95% CI 1.19-2.79) and major amputation (RR 1.90; 95% CI 1.30-2.80) were significantly associated with mortality. Conclusions: CLI is a clinical condition of such severity that most of the recognised cardiovascular riskfactors cannot further influence the fate of the patients, one-third of whom die within 2 years.

Long-term mortality and its predictors in patients with critical leg ischemia

CAO, Piergiorgio;VERZINI, Fabio;MANNARINO, Elmo;Pasqualini, L;
1997

Abstract

Objective: To assess the predictivity of predefined variables with respect to long-term mortality in a cohort of patients with chronic critical leg ischaemia (CLI). Design" Prospective observational study. Methods: Census offices were asked to release information on survival or death status of 574 patients with CLI 2 years after their recruitment in the study. Results: 0f522 patients with available information, 165 (31.6%) died within 2 years of hospitaI admission, mostlyfrom vascular causes as expected. Among the variables considered, male sex, current smoking, arterial hypertension, diabetes metlitus, hypercholesterolaemia, obesity, history of myocardial infarction and low ankle systolic pressure showed no univariate association with mortality. The multivariate analysis also excluded revascularisation procedures and the Fontaine stage as prognostic factors in terms of mortality. Besides age >_70 years (relative risk, RR 1.94; 95% confidence interval (CI) 1.37-2.70), only a history of stroke (RR 1.82; 95% CI 1.19-2.79) and major amputation (RR 1.90; 95% CI 1.30-2.80) were significantly associated with mortality. Conclusions: CLI is a clinical condition of such severity that most of the recognised cardiovascular riskfactors cannot further influence the fate of the patients, one-third of whom die within 2 years.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1221496
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