Squamous cell carcinoma (SCC) is a malignant mucoepithelial tumor that affects pets and farm animals. Common sites are dorsal areas and/or areas of poor skin pigmentation exposed to mutagenic ultraviolet (UV) radiation. Novel ovine papillomavirus (OaPV3) was recently described in SCC lesions in Sardinia breed ovines. In 2017, a 7‑year‑old half‑breed aries was presented with symptoms compatible with a vestibular syndrome. The animal was euthanized 1 month after the onset of clinical signs due to a lack of response to treatment and poor prognosis. A complete postmortem examination was performed. Necropsy revealed only a loss of incisors, associated with alveolar necrotic osteomyelitis, and left unilateral purulent nasal discharge. No other thoracic or abdominal lesions were observed. Opening of the skull revealed a cauliflower‑like space‑occupying mass. Histological examination showed trabecules and islands of squamous, neoplastic epithelial cells with the formation of concentric keratin layers. This raised the suspicion of SCC, which was confirmed with cytokeratin‑positive immunostaining. Simplex PCR on the frozen tissue mass was negative for OaPV1, OaPV2, and OaPV3. This case report suggests that SCC, although rare, should be included in the differential diagnosis of cases of vestibular disorder. Fabrizio Lazzara1*, Federica Giorda1, Katia Varello1, Maria Teresa Mandara2, Simona Zoppi1, Mariella Goria1, Milena Monnier1, Tiziana Avanzato1, Cristina Casalone1 and Barbara Iulini1Intracranial squamous cell carcinoma in an Ovis ariesVeterinaria Italiana 2020, 56 (2), 141‑144. doi: 10.12834/VetIt.1911.10405.2Accepted: 31.01.2020 | Available on line: 31.12.2020
Intracranial squamous cell carcinoma in an Ovis Aries
Maria Teresa Mandara;
2020
Abstract
Squamous cell carcinoma (SCC) is a malignant mucoepithelial tumor that affects pets and farm animals. Common sites are dorsal areas and/or areas of poor skin pigmentation exposed to mutagenic ultraviolet (UV) radiation. Novel ovine papillomavirus (OaPV3) was recently described in SCC lesions in Sardinia breed ovines. In 2017, a 7‑year‑old half‑breed aries was presented with symptoms compatible with a vestibular syndrome. The animal was euthanized 1 month after the onset of clinical signs due to a lack of response to treatment and poor prognosis. A complete postmortem examination was performed. Necropsy revealed only a loss of incisors, associated with alveolar necrotic osteomyelitis, and left unilateral purulent nasal discharge. No other thoracic or abdominal lesions were observed. Opening of the skull revealed a cauliflower‑like space‑occupying mass. Histological examination showed trabecules and islands of squamous, neoplastic epithelial cells with the formation of concentric keratin layers. This raised the suspicion of SCC, which was confirmed with cytokeratin‑positive immunostaining. Simplex PCR on the frozen tissue mass was negative for OaPV1, OaPV2, and OaPV3. This case report suggests that SCC, although rare, should be included in the differential diagnosis of cases of vestibular disorder. Fabrizio Lazzara1*, Federica Giorda1, Katia Varello1, Maria Teresa Mandara2, Simona Zoppi1, Mariella Goria1, Milena Monnier1, Tiziana Avanzato1, Cristina Casalone1 and Barbara Iulini1Intracranial squamous cell carcinoma in an Ovis ariesVeterinaria Italiana 2020, 56 (2), 141‑144. doi: 10.12834/VetIt.1911.10405.2Accepted: 31.01.2020 | Available on line: 31.12.2020I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
