The preparation of an HPLC column with a non-covalent immobilized artificial membrane, by dynamic coating of a RP-18 surface with phosphatidylcholine, is described. Passive transport of unconjugated bile acids has been correlated with log k(w) values resulting from interaction with this biomembrane-like surface.
Use of RP-HPLC on a Dynamically Coated Artificial Membrane to Predict Intestinal Absorption of Bile Acids
NATALINI, Benedetto;CAMAIONI, Emidio;PELLICCIARI, Roberto
2001
Abstract
The preparation of an HPLC column with a non-covalent immobilized artificial membrane, by dynamic coating of a RP-18 surface with phosphatidylcholine, is described. Passive transport of unconjugated bile acids has been correlated with log k(w) values resulting from interaction with this biomembrane-like surface.File in questo prodotto:
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