Enamine activation concept has been successfully extended to the asymmetric introduction of Selenium-based compounds into aldehydes. The main features of this novel organocatalytic transformation rely on the high levels of reaction efficiency and stereocontrol (ee ranging from 95% to 99%) obtained using easily available chiral secondary amines along with the high synthetic utility of the chiral α-seleno aldehydes, versatile chiral intermediates for a variety of different synthetic transformations.

Organocatalytic Asymmetric alpha-Selenenylation of Aldehydes.

TIECCO, Marcello;STERNATIVO, Silvia;MARINI, Francesca
;
2007

Abstract

Enamine activation concept has been successfully extended to the asymmetric introduction of Selenium-based compounds into aldehydes. The main features of this novel organocatalytic transformation rely on the high levels of reaction efficiency and stereocontrol (ee ranging from 95% to 99%) obtained using easily available chiral secondary amines along with the high synthetic utility of the chiral α-seleno aldehydes, versatile chiral intermediates for a variety of different synthetic transformations.
2007
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/151994
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 96
  • ???jsp.display-item.citation.isi??? 91
social impact