Enamine activation concept has been successfully extended to the asymmetric introduction of Selenium-based compounds into aldehydes. The main features of this novel organocatalytic transformation rely on the high levels of reaction efficiency and stereocontrol (ee ranging from 95% to 99%) obtained using easily available chiral secondary amines along with the high synthetic utility of the chiral α-seleno aldehydes, versatile chiral intermediates for a variety of different synthetic transformations.
Organocatalytic Asymmetric alpha-Selenenylation of Aldehydes.
TIECCO, Marcello;STERNATIVO, Silvia;MARINI, Francesca
;
2007
Abstract
Enamine activation concept has been successfully extended to the asymmetric introduction of Selenium-based compounds into aldehydes. The main features of this novel organocatalytic transformation rely on the high levels of reaction efficiency and stereocontrol (ee ranging from 95% to 99%) obtained using easily available chiral secondary amines along with the high synthetic utility of the chiral α-seleno aldehydes, versatile chiral intermediates for a variety of different synthetic transformations.File in questo prodotto:
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