Currently, chronic obstructive pulmonary disease (COPD) represents the fourth cause of death worldwide with significant economic burden. Comorbidities increase in number and severity with age and are identified as important determinants that influence the prognosis. In this observational study, we retrospectively analyzed data collected from the RePoSI register. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients with the clinical diagnosis of COPD. Socio-demographic, clinical characteristics and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up were analyzed. Among 4696 in-patients, 932 (19.8%) had a diagnosis of COPD. Patients with COPD had more hospitalization, a significant overt cognitive impairment, a clinically significant disability and more depression in comparison with non-COPD subjects. COPD patients took more drugs, both at admission, in-hospital stay, discharge and 3-month and 1-year follow-up. 14 comorbidities were more frequent in COPD patients. Cerebrovascular disease was an independent predictor of in-hospital mortality. At 3-month follow-up, male sex and hepatic cirrhosis were independently associated with mortality. ICS-LABA therapy was predictor of mortality at in-hospital, 3-month and 1-year follow-up. This analysis showed the severity of impact of COPD and its comorbidities in the real life of internal medicine and geriatric wards.

Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry

Domenico Prisco
Membro del Collaboration Group
;
Graziana Lupattelli
Membro del Collaboration Group
;
Elmo Mannarino
Membro del Collaboration Group
;
Vanessa Bianconi
Membro del Collaboration Group
;
Francesco Paciullo
Membro del Collaboration Group
;
Riccardo Alcidi
Membro del Collaboration Group
;
Elisa Fabbri
Membro del Collaboration Group
;
Maria Domenica Cappellini
Membro del Collaboration Group
;
Federica Conti
Membro del Collaboration Group
;
Lucia Sofia
Membro del Collaboration Group
;
Maria Carbone
Membro del Collaboration Group
;
Paolo Mazzola
Membro del Collaboration Group
;
Marco Bertolotti
Membro del Collaboration Group
;
Elisa Pellegrini
Membro del Collaboration Group
;
Roberto Leonardi
Membro del Collaboration Group
;
Massimo Mattioli
Membro del Collaboration Group
;
Lorenzo Biondi
Membro del Collaboration Group
;
Maria Pasquale
Membro del Collaboration Group
;
Giuseppe Montalto
Membro del Collaboration Group
;
Patrizia Mecocci
Membro del Collaboration Group
;
Carmelinda Ruggiero
Membro del Collaboration Group
;
Virginia Boccardi
Membro del Collaboration Group
;
Roberto Tarquini
Membro del Collaboration Group
;
Riccardo Volpi
Membro del Collaboration Group
;
2021-01-01

Abstract

Currently, chronic obstructive pulmonary disease (COPD) represents the fourth cause of death worldwide with significant economic burden. Comorbidities increase in number and severity with age and are identified as important determinants that influence the prognosis. In this observational study, we retrospectively analyzed data collected from the RePoSI register. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients with the clinical diagnosis of COPD. Socio-demographic, clinical characteristics and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up were analyzed. Among 4696 in-patients, 932 (19.8%) had a diagnosis of COPD. Patients with COPD had more hospitalization, a significant overt cognitive impairment, a clinically significant disability and more depression in comparison with non-COPD subjects. COPD patients took more drugs, both at admission, in-hospital stay, discharge and 3-month and 1-year follow-up. 14 comorbidities were more frequent in COPD patients. Cerebrovascular disease was an independent predictor of in-hospital mortality. At 3-month follow-up, male sex and hepatic cirrhosis were independently associated with mortality. ICS-LABA therapy was predictor of mortality at in-hospital, 3-month and 1-year follow-up. This analysis showed the severity of impact of COPD and its comorbidities in the real life of internal medicine and geriatric wards.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1538257
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