As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration andinevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug-drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Societa Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.

Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register

Elmo Mannarino
Membro del Collaboration Group
;
Graziana Lupattelli
Membro del Collaboration Group
;
Vanessa Bianconi
Membro del Collaboration Group
;
Francesco Paciullo
Membro del Collaboration Group
;
Oliviero Olivieri
Membro del Collaboration Group
;
Maria Domenica Cappellini
Membro del Collaboration Group
;
Federica Conti
Membro del Collaboration Group
;
Maria Carbone
Membro del Collaboration Group
;
Paolo Mazzola
Membro del Collaboration Group
;
Marco Bertolotti
Membro del Collaboration Group
;
Elisa Pellegrini
Membro del Collaboration Group
;
Roberto Leonardi
Membro del Collaboration Group
;
Massimo Mattioli
Membro del Collaboration Group
;
Lorenzo Biondi
Membro del Collaboration Group
;
Maria Pasquale
Membro del Collaboration Group
;
Giuseppe Montalto
Membro del Collaboration Group
;
Patrizia Mecocci
Membro del Collaboration Group
;
Carmelinda Ruggiero
Membro del Collaboration Group
;
Virginia Boccardi
Membro del Collaboration Group
;
Roberto Tarquini
Membro del Collaboration Group
;
Riccardo Volpi
Membro del Collaboration Group
;
2018-01-01

Abstract

As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration andinevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug-drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Societa Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1538271
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