Introduction: Thymosin 4 (T4) is a thymic hormone with multiple and different intracellular and extracellular activities affecting wound healing, inflammation, fibrosis and tissue regeneration. As the failure to resolve inflammation leads to uncontrolled inflammatory pathology which underlies many chronic diseases, the endogenous pathway through which T4 may promote inflammation resolution becomes of great interest. In this review, we discuss data highlighting the efficacy of T4 in resolving inflammation by restoring autophagy.Areas covered: The authors provide an overview of the T4's anti-inflammatory properties in several pathologies and provide preliminary evidence on the ability of T4 to resolve inflammation via the promotion of non-canonical autophagy associated with the activation of the DAP kinase anti-inflammatory function.Expert opinion: Based on its multitasking activity in various animal studies, including tissue repair and prevention of chronic inflammation, T4 may represent a potential, novel treatment for inflammatory diseases associated with defective autophagy.

Thymosin β4 limits inflammation through autophagy

Renga, Giorgia;Oikonomou, Vasilis;Stincardini, Claudia;Pariano, Marilena;Borghi, Monica;Costantini, Claudio;Bartoli, Andrea;Romani, Luigina
2018-01-01

Abstract

Introduction: Thymosin 4 (T4) is a thymic hormone with multiple and different intracellular and extracellular activities affecting wound healing, inflammation, fibrosis and tissue regeneration. As the failure to resolve inflammation leads to uncontrolled inflammatory pathology which underlies many chronic diseases, the endogenous pathway through which T4 may promote inflammation resolution becomes of great interest. In this review, we discuss data highlighting the efficacy of T4 in resolving inflammation by restoring autophagy.Areas covered: The authors provide an overview of the T4's anti-inflammatory properties in several pathologies and provide preliminary evidence on the ability of T4 to resolve inflammation via the promotion of non-canonical autophagy associated with the activation of the DAP kinase anti-inflammatory function.Expert opinion: Based on its multitasking activity in various animal studies, including tissue repair and prevention of chronic inflammation, T4 may represent a potential, novel treatment for inflammatory diseases associated with defective autophagy.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1538857
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