Functional 1H-MRS findings in migraine patients with and without aura assessed interictally.

The present study was aimed at investigating changes in brain metabolites due to visual cortex activation in migraineurs and normal subjects by 1H-magnetic resonance spectroscopy (MRS). Twenty-two migraine patients with aura, 22 migraine patients without aura, and 10 control subjects were assessed. The volume of interest (about 8 cm3) was placed on the visual cortex area and the visual stimulus was applied using MR-compatible goggles with a flashing red light at a frequency of 8 Hz and an intensity of 14 lx. Data were acquired over 36V40U. The experimental time course was: baseline phase, from 0 to 3V40U (1 spectrum); on phase (flashing light condition), from 3V40U to 29V20U (1540U) (7 spectra), and off phase, from 29V20U to the end of the experiment at 36V40U (2 spectra). The main result of photic stimulation in patients with migraine with aura is the more consistent decrease (-14.61%) of the N-acetylaspartate (NAA) signal, which is significantly greater than that found in migraine patients without aura and control subjects. A parallel slight increase in the lactate peak was also detected.The above findings support little differences in brain metabolites between the two patient groups assessed in interictal periods, which suggests a less efficient mitochondrial functioning in migraine with aura patients.