A series of 2′,3′-dideoxy-N6-(cyclo)alkyl-1-deazaadenosine derivatives were synthesized starting from 2,6-dichloro-1-deazapurine (9). The new nucleosides proved to be good inhibitors of HIV-1 replication, the most active being the 2′,3′-dideoxy-2-chloro-N6-cycloctyl-1-deazaadenosine (14h, ED50 = 0.4 μ).
Inhibitory Effects of 1-Deazaadenosine Analogues on HIV Replication and Adenosine Deaminase
CAMAIONI, Emidio;
1995
Abstract
A series of 2′,3′-dideoxy-N6-(cyclo)alkyl-1-deazaadenosine derivatives were synthesized starting from 2,6-dichloro-1-deazapurine (9). The new nucleosides proved to be good inhibitors of HIV-1 replication, the most active being the 2′,3′-dideoxy-2-chloro-N6-cycloctyl-1-deazaadenosine (14h, ED50 = 0.4 μ).File in questo prodotto:
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