The optimal site for microencapsulated pancreatic islet transplantation in large size-mammalians remains undetermined. Twenty-three female Large-White pigs were prospectively randomized into two groups: Group 1 (n= 11 animals) was used to assess biocompatibility as well as in vivo reactivity elicited by empty microxcapsules; Group 2 (n= 12 animals) was used to determine both the islet and the extent, if any of peri-capsular cellular overgrowth upon encapsulated islet allograft. Biocompatibility of the membrane materials was high while no activation of lymphocytes or induction of peri-capsular inflammatory cell reaction were observed. At 28 days of transplation the retrieved microencapsulated islets were fully viable and had provoked minimal inflammatory reaction at the level of the liver and omentum, with minor differences being detected in the mesentery.
TRANSPLANTATION OF ISLET ENVELOPED IN ALGINATE/POLYAMINOACIDIC COHERENT MICROCAPSULES IN ADULT PIGS
BOSELLI, Carlo;BUFALARI, Antonello;CIROCCHI, Roberto;P. Ricci;LUCA, Giovanni;BUFALARI, Antonello;MORICONI, Franco;GIUSTOZZI, Giammario;BROZZETTI, Annalisa;BRUNETTI, Paolo;MOGGI, Luigi;CALAFIORE, Riccardo
2001
Abstract
The optimal site for microencapsulated pancreatic islet transplantation in large size-mammalians remains undetermined. Twenty-three female Large-White pigs were prospectively randomized into two groups: Group 1 (n= 11 animals) was used to assess biocompatibility as well as in vivo reactivity elicited by empty microxcapsules; Group 2 (n= 12 animals) was used to determine both the islet and the extent, if any of peri-capsular cellular overgrowth upon encapsulated islet allograft. Biocompatibility of the membrane materials was high while no activation of lymphocytes or induction of peri-capsular inflammatory cell reaction were observed. At 28 days of transplation the retrieved microencapsulated islets were fully viable and had provoked minimal inflammatory reaction at the level of the liver and omentum, with minor differences being detected in the mesentery.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
