The synthesis and a conformational study of a number of homologues of the well known antibiotic, phytotoxic leucinostatin A are reported. The circular dichroism of all the compounds are discussed. Some conclusions on the SAR of these compounds are drawn. The influence od the alpha-helical conformation and/or the increased lipophile character on their interesting biological activities is emphasized.
Structure activity studies on chemically modified homologues of the antibiotic phytotoxic leucinostatin A.
RICCI, Maurizio;ROSSI, Carlo
1995
Abstract
The synthesis and a conformational study of a number of homologues of the well known antibiotic, phytotoxic leucinostatin A are reported. The circular dichroism of all the compounds are discussed. Some conclusions on the SAR of these compounds are drawn. The influence od the alpha-helical conformation and/or the increased lipophile character on their interesting biological activities is emphasized.File in questo prodotto:
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