The synthesis and a conformational study of a number of homologues of the well known antibiotic, phytotoxic leucinostatin A are reported. The circular dichroism of all the compounds are discussed. Some conclusions on the SAR of these compounds are drawn. The influence od the alpha-helical conformation and/or the increased lipophile character on their interesting biological activities is emphasized.

Structure activity studies on chemically modified homologues of the antibiotic phytotoxic leucinostatin A.

RICCI, Maurizio;ROSSI, Carlo
1995

Abstract

The synthesis and a conformational study of a number of homologues of the well known antibiotic, phytotoxic leucinostatin A are reported. The circular dichroism of all the compounds are discussed. Some conclusions on the SAR of these compounds are drawn. The influence od the alpha-helical conformation and/or the increased lipophile character on their interesting biological activities is emphasized.
1995
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/923408
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