The synthesis of a new series of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo [3,4-d]-1,5-benzothiazepine has been accomplished starting from 2,3-dihydro-1,5-benzothiazepin-4(5H)ones and their 2-methyl and 2-aryl derivatives. All the compounds were tested in vitro for their antimicrobial activity, but none of them showed remarkable activity- The tricyclic compounds 7a-j, 9a-j, 10a-j, and 11a-j were also screened for their CNS activity in mice and several of them showed interesting activity.

Studies on annelated [1,4]benzothiazines and [1,5]benzothiaepines, V: Synthesis and biological activity of n-2 alkylamino derivatives of 4,5-dihydro-s-triazolo [3,4-d]-1,5-benzothiazepine.

AMBROGI, Valeria;PERIOLI, Luana;RICCI, Maurizio;
1992

Abstract

The synthesis of a new series of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo [3,4-d]-1,5-benzothiazepine has been accomplished starting from 2,3-dihydro-1,5-benzothiazepin-4(5H)ones and their 2-methyl and 2-aryl derivatives. All the compounds were tested in vitro for their antimicrobial activity, but none of them showed remarkable activity- The tricyclic compounds 7a-j, 9a-j, 10a-j, and 11a-j were also screened for their CNS activity in mice and several of them showed interesting activity.
1992
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/923495
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