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Il Partito Popolare Italiano a Perugia (1919-1925)

Il contributo ricostruisce la storia del Ppi in Umbria dalla fine della Prima guerra mondiale alle leggi fascistissime attraverso lo spoglio delle fonti a stampa cattoliche e liberali ("L'Umbria", "Il Lavoratore" e "L'Unione liberale") e grazie allo studio di alcuni fondi archivistici custoditi dall'Istituto Sturzo di Roma. Particolare attenzione viene attribuita ai rapporti tra il Ppi, la Gerarchia ecclesiastica e i sindacati bianchi. Senza dubbio, il punto di riferimento del popolarismo per...

GRB 221009A: The B.O.A.T. Burst that Shines in Gamma Rays

We present a complete analysis of Fermi Large Area Telescope (LAT) data of GRB 221009A, the brightest gamma-ray burst (GRB) ever detected. The burst emission above 30 MeV detected by the LAT preceded, by 1 s, the low-energy (<10 MeV) pulse that triggered the Fermi Gamma-Ray Burst Monitor (GBM), as has been observed in other GRBs. The prompt phase of GRB 221009A lasted a few hundred seconds. It was so bright that we identify a bad time interval of 64 s caused by the extremely high flux of h...

Fermi detection of gamma-ray emission from the hot coronae of radio-quiet active galactic nuclei

Relativistic jets around supermassive black holes are well-known powerful γ-ray emitters. In the absence of the jets in radio-quiet active galactic nuclei, how the supermassive black holes work in γ-ray bands is still unknown despite great observational efforts in the past three decades. Here, considering the previous efforts, we carefully select an active galactic nucleus sample composed of 37 nearby Seyfert galaxies with ultrahard X-rays for γ-ray detection by excluding all potential contam...

Phenomenological pedagogy. Training Educators in Applied Phenomenology

This volume covers the application of phenomenology not only to psychology and psychiatry but precisely to pedagogy and the training of educators. It fills a gap in offering a unique resource which combines both theory and practice. Through an interdisciplinary means, this book provides new theories and applications of phenomenological pedagogy at all levels of education and with a unique focus on autism and special educational needs. It proposes a shift in the paradigm and treatment: from a ...

Optimization of Lipoplexes Functionalized with a Sialic Acid Mimetic (F9-PEG) to Target the C1858T PTPN22 Variant for Preclinical Assessment of a Novel Immunotherapy in Endocrine Autoimmunity

Background: The C1858T PTPN22 variant is strongly associated with type 1 diabetes and autoimmune thyroid disease. Current treatment is substitutive hormonal administration, which does not target the disease pathogenetic mechanism. We previously implemented a novel immunotherapy, employing siRNA directed against the C1858T variant of PTPN22 delivered via functionalized lipoplexes, in order to halt autoimmune disease progression. Objectives: The objective of this study was to optimize lipoplex ...

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