NUTI, ROBERTO
NUTI, ROBERTO
DIPARTIMENTO DI MEDICINA SPERIMENTALE (attivo dal 01/01/2014 al 31/10/2020)
Adamantyl-substituted retinoid-derived molecules that intercact with the orphan nuclear receptor small heterodimer partner:effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity
2008 M. I., Dawson; Z., Xia; T., Jiang; M., Ye; J. A., Fontana; L., Farhana; B., Patel; L. P., Xue; M., Bhuiyan; Macchiarulo, Antonio; Nuti, Roberto; X. K., Zhang; Y. H., Han; L., Tautz; P. D., Hobbs; L., Jong; N., Walech; W. R., Chao; G. S., Feng; Y., Pang; Pellicciari, Roberto
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators
2012 Pellicciari, Roberto; Gioiello, Antimo; P., Sabbatini; F., Venturoni; Nuti, Roberto; C., Colliva; G., Rizzo; L., Adorini; M., Pruzanski; A., Roda; Macchiarulo, Antonio
Charting the chemical space of target sites: insights into the binding modes of amine and amidine groups.
2009 Macchiarulo, Antonio; Nuti, Roberto; Eren, G; Pellicciari, Roberto
Choline Kinase Active Site Provides Features for Designing Versatile Inhibitors
2014 L., Serran Aguilera; Nuti, Roberto; L. C., Lopez Cara; P., Rios Marco; M. P., Carrasco; C., Marco; A., Entrena; Macchiarulo, Antonio; R., Hurtado Guerrero
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids
2010 Natalini, Benedetto; Sardella, Roccaldo; Gioiello, Antimo; E., Rosatelli; Nuti, Roberto; Camaioni, Emidio; Macchiarulo, Antonio; Pellicciari, Roberto
Combined strategies toward the design and synthesis, of novel inhibitors of indoleamine-2,3-dioxygenase (IDO)
2009 Camaioni, Emidio; G., Pittelli; P., Liscio; Nuti, Roberto; Macchiarulo, Antonio; Sardella, Roccaldo; A., Chiarugi; F., Moroni; Pellicciari, Roberto
Effects of Molecular Dynamics and Replica Exchange Molecular Dynamics in Sampling the Conformational Space of PARP-1
2013 Antolin, Albert A.; Carotti, Andrea; Nuti, Roberto; Hakkaya, Aydie; Camaioni, Emidio; Mestres, Jordi; Pellicciari, Roberto; Macchiarulo, Antonio
Exploring Ligand Recognition in the Kynurenine Pathway to Advance the Medicinal Chemistry of Kynurenines
2009 Macchiarulo, Antonio; L., Amori; D., Bellocchi; Camaioni, Emidio; Carotti, Andrea; A., Chiarugi; Costantino, Gabriele; Marinozzi, Maura; Nuti, Roberto; . F., Venturoni; R., Schwarcz; F., Moroni; Pellicciari, Roberto
Exploring the effect of PARP-1 flexibility in docking studies
2013 Albert A., Antolin; Carotti, Andrea; Nuti, Roberto; Aydie, Hakkaya; Camaioni, Emidio; Jordi, Mestres; Roberto, Pellicciari; Macchiarulo, Antonio
Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design
2012 Custodi, Chiara; Nuti, Roberto; Tudor I., Oprea; Macchiarulo, Antonio
High-throughput chromatographic determination of the bile acid critical micellar concentration
2010 Natalini, Benedetto; Sardella, Roccaldo; Gioiello, Antimo; E., Rosatelli; Nuti, Roberto; Camaioni, Emidio; Macchiarulo, Antonio; Pellicciari, Roberto
Highlights at the gate of tryptophan catabolism: a review on the mechanism of activation and regulation of indoleamine 2,3-dioxigenase (IDO), a novel target in cancer disease
2009 Macchiarulo, Antonio; Camaioni, Emidio; Nuti, Roberto; Pellicciari, Roberto
Ligand Binding and Functional Selectivity ofl-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR)
2014 Nuti, Roberto; Gargaro, Marco; Matino, Davide; Daniela, Dolciami; Grohmann, Ursula; Puccetti, Paolo; Fallarino, Francesca; Macchiarulo, Antonio
Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in indoleamine-2,3-dioxygenase (IDO).
2007 Macchiarulo, Antonio; Nuti, Roberto; Bellocchi, D.; Camaioni, Emidio; Pellicciari, Roberto
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5.
2008 Macchiarulo, Antonio; Gioiello, Antimo; Thomas, C.; Massarotti, A.; Nuti, Roberto; Rosatelli, E.; Sabbatini, P.; Schoonjans, K.; Auwerx, J.; Pellicciari, Roberto
Molecular field analysis and quantitative structure-activity studies (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5 receptor.
2008 Gioiello, Antimo; Macchiarulo, Antonio; Thomas, C.; Massarotti, A.; Nuti, Roberto; Rosatelli, E.; Sabatini, P.; Schoonjans, K.; Auwerx, J.; Pellicciari, Roberto
Novel method for generating structure-based pharmacophores using energetic analysis.
2009 Salam, Nk; Nuti, Roberto; Sherman, W.
Patented TGR5 modulators: a review (2006 - present)
2012 Gioiello, Antimo; Rosatelli, E; Nuti, Roberto; Macchiarulo, Antonio; Pellicciari, Roberto
Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1
2015 Serrán Aguilera, L; Nuti, Roberto; López Cara, Lc; Mezo, Ma; Macchiarulo, Antonio; Entrena, A; Hurtado Guerrero, R.
Probing the Binding Site of Bile Acids in TGR5
2013 Macchiarulo, Antonio; Gioiello, Antimo; Thomas, C; Pols, Twh; Nuti, Roberto; Ferrari, C; Giacche, N; De Franco, F; Pruzanski, M; Auwerx, J.; Schoonjans, K; Pellicciari, R.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Adamantyl-substituted retinoid-derived molecules that intercact with the orphan nuclear receptor small heterodimer partner:effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity | 2008 | M. I., Dawson; Z., Xia; T., Jiang; M., Ye; J. A., Fontana; L., Farhana; B., Patel; L. P., Xue; M., Bhuiyan; Macchiarulo, Antonio; Nuti, Roberto; X. K., Zhang; Y. H., Han; L., Tautz; P. D., Hobbs; L., Jong; N., Walech; W. R., Chao; G. S., Feng; Y., Pang; Pellicciari, Roberto | |
| Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators | 2012 | Pellicciari, Roberto; Gioiello, Antimo; P., Sabbatini; F., Venturoni; Nuti, Roberto; C., Colliva; G., Rizzo; L., Adorini; M., Pruzanski; A., Roda; Macchiarulo, Antonio | |
| Charting the chemical space of target sites: insights into the binding modes of amine and amidine groups. | 2009 | Macchiarulo, Antonio; Nuti, Roberto; Eren, G; Pellicciari, Roberto | |
| Choline Kinase Active Site Provides Features for Designing Versatile Inhibitors | 2014 | L., Serran Aguilera; Nuti, Roberto; L. C., Lopez Cara; P., Rios Marco; M. P., Carrasco; C., Marco; A., Entrena; Macchiarulo, Antonio; R., Hurtado Guerrero | |
| Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids | 2010 | Natalini, Benedetto; Sardella, Roccaldo; Gioiello, Antimo; E., Rosatelli; Nuti, Roberto; Camaioni, Emidio; Macchiarulo, Antonio; Pellicciari, Roberto | |
| Combined strategies toward the design and synthesis, of novel inhibitors of indoleamine-2,3-dioxygenase (IDO) | 2009 | Camaioni, Emidio; G., Pittelli; P., Liscio; Nuti, Roberto; Macchiarulo, Antonio; Sardella, Roccaldo; A., Chiarugi; F., Moroni; Pellicciari, Roberto | |
| Effects of Molecular Dynamics and Replica Exchange Molecular Dynamics in Sampling the Conformational Space of PARP-1 | 2013 | Antolin, Albert A.; Carotti, Andrea; Nuti, Roberto; Hakkaya, Aydie; Camaioni, Emidio; Mestres, Jordi; Pellicciari, Roberto; Macchiarulo, Antonio | |
| Exploring Ligand Recognition in the Kynurenine Pathway to Advance the Medicinal Chemistry of Kynurenines | 2009 | Macchiarulo, Antonio; L., Amori; D., Bellocchi; Camaioni, Emidio; Carotti, Andrea; A., Chiarugi; Costantino, Gabriele; Marinozzi, Maura; Nuti, Roberto; . F., Venturoni; R., Schwarcz; F., Moroni; Pellicciari, Roberto | |
| Exploring the effect of PARP-1 flexibility in docking studies | 2013 | Albert A., Antolin; Carotti, Andrea; Nuti, Roberto; Aydie, Hakkaya; Camaioni, Emidio; Jordi, Mestres; Roberto, Pellicciari; Macchiarulo, Antonio | |
| Fitting the complexity of GPCRs modulation into simple hypotheses of ligand design | 2012 | Custodi, Chiara; Nuti, Roberto; Tudor I., Oprea; Macchiarulo, Antonio | |
| High-throughput chromatographic determination of the bile acid critical micellar concentration | 2010 | Natalini, Benedetto; Sardella, Roccaldo; Gioiello, Antimo; E., Rosatelli; Nuti, Roberto; Camaioni, Emidio; Macchiarulo, Antonio; Pellicciari, Roberto | |
| Highlights at the gate of tryptophan catabolism: a review on the mechanism of activation and regulation of indoleamine 2,3-dioxigenase (IDO), a novel target in cancer disease | 2009 | Macchiarulo, Antonio; Camaioni, Emidio; Nuti, Roberto; Pellicciari, Roberto | |
| Ligand Binding and Functional Selectivity ofl-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR) | 2014 | Nuti, Roberto; Gargaro, Marco; Matino, Davide; Daniela, Dolciami; Grohmann, Ursula; Puccetti, Paolo; Fallarino, Francesca; Macchiarulo, Antonio | |
| Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in indoleamine-2,3-dioxygenase (IDO). | 2007 | Macchiarulo, Antonio; Nuti, Roberto; Bellocchi, D.; Camaioni, Emidio; Pellicciari, Roberto | |
| Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. | 2008 | Macchiarulo, Antonio; Gioiello, Antimo; Thomas, C.; Massarotti, A.; Nuti, Roberto; Rosatelli, E.; Sabbatini, P.; Schoonjans, K.; Auwerx, J.; Pellicciari, Roberto | |
| Molecular field analysis and quantitative structure-activity studies (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5 receptor. | 2008 | Gioiello, Antimo; Macchiarulo, Antonio; Thomas, C.; Massarotti, A.; Nuti, Roberto; Rosatelli, E.; Sabatini, P.; Schoonjans, K.; Auwerx, J.; Pellicciari, Roberto | |
| Novel method for generating structure-based pharmacophores using energetic analysis. | 2009 | Salam, Nk; Nuti, Roberto; Sherman, W. | |
| Patented TGR5 modulators: a review (2006 - present) | 2012 | Gioiello, Antimo; Rosatelli, E; Nuti, Roberto; Macchiarulo, Antonio; Pellicciari, Roberto | |
| Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1 | 2015 | Serrán Aguilera, L; Nuti, Roberto; López Cara, Lc; Mezo, Ma; Macchiarulo, Antonio; Entrena, A; Hurtado Guerrero, R. | |
| Probing the Binding Site of Bile Acids in TGR5 | 2013 | Macchiarulo, Antonio; Gioiello, Antimo; Thomas, C; Pols, Twh; Nuti, Roberto; Ferrari, C; Giacche, N; De Franco, F; Pruzanski, M; Auwerx, J.; Schoonjans, K; Pellicciari, R. |