Purpose of the study A high prevalence of bone demineralization has been reported in HIV-infected patients, but its aetiology and mechanism are still unknown. Prevalence estimates vary widely and may be influenced by antiretroviral therapy, lipodystrophy, severity of HIV disease, and overlapping bone loss risk factors. We sought to assess bone metabolism and calcium intake in HIV-infected patients, naïve or treated with HAART. Methods From February 1, 2008, 100 consecutive outpatients attending the Department of Infectious Disease, Perugia Hospital, were included in this study. Every patient was screened for serum level of 25 (OH) vitamin D, parathyroid hormone (PTH), bone-specific alkaline phosphatase (BALP), serum crosslaps, calcium and phosphate. A questionnaire on consumption of calcium-containing foods was administered. Data on race, age, BMI, duration of infection and HAART, smoking, alcohol, viral load and CD4+ cells count were collected from our medical records.
Biochemical markers of bone turnover and calcium dietary intake evaluation in HIV-infected patients
CAMANNI, Guido;TORALDO, Gianluca;ROSIGNOLI, DANIELE;PIPPI, Romeo;SCHIAROLI, ELISABETTA;ANGELETTI, Gabriella;BALDELLI, Franco;FRANCISCI, Daniela
2008
Abstract
Purpose of the study A high prevalence of bone demineralization has been reported in HIV-infected patients, but its aetiology and mechanism are still unknown. Prevalence estimates vary widely and may be influenced by antiretroviral therapy, lipodystrophy, severity of HIV disease, and overlapping bone loss risk factors. We sought to assess bone metabolism and calcium intake in HIV-infected patients, naïve or treated with HAART. Methods From February 1, 2008, 100 consecutive outpatients attending the Department of Infectious Disease, Perugia Hospital, were included in this study. Every patient was screened for serum level of 25 (OH) vitamin D, parathyroid hormone (PTH), bone-specific alkaline phosphatase (BALP), serum crosslaps, calcium and phosphate. A questionnaire on consumption of calcium-containing foods was administered. Data on race, age, BMI, duration of infection and HAART, smoking, alcohol, viral load and CD4+ cells count were collected from our medical records.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
