Ordered mesoporous silicates have been recently proposed as drug carriers because of their peculiar characteristics which enables them to host drugs inside their ordered mesopores and then to release them. Many different applications have been proposed such as drug controlled release, targeted delivery and poorly water-soluble drug dissolution rate improvement. Poor solubility of a drug is one of the most serious problem in the development of a pharmaceutical product and ordered mesoporous silicates have been proposed as agents to decrease/solve this problem. Among them, MCM-41 and SBA-15 are the most studied. This chapter reviews the research work in this area and present results on different drug loading procedures, the influence of pore size and drug physical stability. A comparison with other porous inorganic matrices is discussed as well.
Ordered mesoporous silicates MCM-41 and SBA-15 as matrices for improving dissolution rate of poorly water soluble drugs
AMBROGI, Valeria
2015
Abstract
Ordered mesoporous silicates have been recently proposed as drug carriers because of their peculiar characteristics which enables them to host drugs inside their ordered mesopores and then to release them. Many different applications have been proposed such as drug controlled release, targeted delivery and poorly water-soluble drug dissolution rate improvement. Poor solubility of a drug is one of the most serious problem in the development of a pharmaceutical product and ordered mesoporous silicates have been proposed as agents to decrease/solve this problem. Among them, MCM-41 and SBA-15 are the most studied. This chapter reviews the research work in this area and present results on different drug loading procedures, the influence of pore size and drug physical stability. A comparison with other porous inorganic matrices is discussed as well.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
