Protein-protein interactions (PPI) are central to most biological process and include aspects such as viral self-assembly, cell proliferation, growth, differentiation, signal transduction, and programmed cell death [1], and the last decade has seen an explosion of interest [2-4]. The human interactome has been estimated to involve ∼25,000 proteins and ∼650,000 interactions [5], and currently, only about 0.3 % of these have been identified [6]. In silico approaches targeting PPIs are still limited, however the versatility of GRID Molecular Interaction Fields is demonstrated through several case studies that explore how novel PPI inhibitors can be identified. © 2013 Springer-Verlag Berlin Heidelberg. All rights are reserved.
Disrupting protein-protein interfaces using GRID Molecular Interaction Fields
Baroni, Massimo;Alcaro, Stefano;Cruciani, Gabriele
2013
Abstract
Protein-protein interactions (PPI) are central to most biological process and include aspects such as viral self-assembly, cell proliferation, growth, differentiation, signal transduction, and programmed cell death [1], and the last decade has seen an explosion of interest [2-4]. The human interactome has been estimated to involve ∼25,000 proteins and ∼650,000 interactions [5], and currently, only about 0.3 % of these have been identified [6]. In silico approaches targeting PPIs are still limited, however the versatility of GRID Molecular Interaction Fields is demonstrated through several case studies that explore how novel PPI inhibitors can be identified. © 2013 Springer-Verlag Berlin Heidelberg. All rights are reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
