Streamlining C1 Homologation Reactions Using Continuous Flow Technology: Focus on Diazomethane and Methyllithium Chemistry

This chapter will cover recent progresses in homologation reactions conducted under flow conditions using diazo compounds, mainly diazomethane and lithium carbenoids. In particular, the chapter aims to highlight advances in processes and equipment concepts for the generation, the control, and the use of hazardous diazomethane and highly reactive organolithiums. Alongside the well-known benefits of flow technology in terms of safety, selectivity, and productivity, particular attention will be devoted on how to perform transformations that are difficult to realize by conventional approaches. The chapter will also cover methodological, technical aspects, and synthetic applications including multistep synthesis, process, and medicinal chemistry.