Phenols may contribute to the chemopreventive effects exerted by olive oil against cancer. Hydroxytyrosol and other olive oil phenolic compounds demonstrated both anti-initiation and antipromotion/progression properties. The anti-initiation effect consists of the prevention of oxidative DNA damage and is mediated by the antioxidant capacity of phenols exerted at low concentrations. The antipromotion/progression effect depends on the capability of phenols to inhibit the proliferation and to induce apoptosis and differentiation in tumor cells at high concentrations. The mechanisms involved in the antipromotion/progression characteristics of phenols include both alteration of the gene expression and modulation of the phosphorylation state of important targets of the signal transduction pathways.A pro-oxidant activity of olive oil phenols at high concentrations has been hypothesized.

Anticarcinogenic Properties of Olive Oil Phenols: Effects on Proliferation, Apoptosis and Differentiation

FABIANI, Roberto;MOROZZI, Guido
2010

Abstract

Phenols may contribute to the chemopreventive effects exerted by olive oil against cancer. Hydroxytyrosol and other olive oil phenolic compounds demonstrated both anti-initiation and antipromotion/progression properties. The anti-initiation effect consists of the prevention of oxidative DNA damage and is mediated by the antioxidant capacity of phenols exerted at low concentrations. The antipromotion/progression effect depends on the capability of phenols to inhibit the proliferation and to induce apoptosis and differentiation in tumor cells at high concentrations. The mechanisms involved in the antipromotion/progression characteristics of phenols include both alteration of the gene expression and modulation of the phosphorylation state of important targets of the signal transduction pathways.A pro-oxidant activity of olive oil phenols at high concentrations has been hypothesized.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/38024
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