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EnglishPhenols may contribute to the chemopreventive effects exerted by olive oil against cancer. Hydroxytyrosol and other olive oil phenolic compounds demonstrated both anti-initiation and antipromotion/progression properties. The anti-initiation effect consists of the prevention of oxidative DNA damage and is mediated by the antioxidant capacity of phenols exerted at low concentrations. The antipromotion/progression effect depends on the capability of phenols to inhibit the proliferation and to induce apoptosis and differentiation in tumor cells at high concentrations. The mechanisms involved in the antipromotion/progression characteristics of phenols include both alteration of the gene expression and modulation of the phosphorylation state of important targets of the signal transduction pathways.A pro-oxidant activity of olive oil phenols at high concentrations has been hypothesized.
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| Titolo: | Anticarcinogenic Properties of Olive Oil Phenols: Effects on Proliferation, Apoptosis and Differentiation |
| Autori: | |
| Data di pubblicazione: | 2010 |
| Abstract: | Phenols may contribute to the chemopreventive effects exerted by olive oil against cancer. Hydroxytyrosol and other olive oil phenolic compounds demonstrated both anti-initiation and antipromotion/progression properties. The anti-initiation effect consists of the prevention of oxidative DNA damage and is mediated by the antioxidant capacity of phenols exerted at low concentrations. The antipromotion/progression effect depends on the capability of phenols to inhibit the proliferation and to induce apoptosis and differentiation in tumor cells at high concentrations. The mechanisms involved in the antipromotion/progression characteristics of phenols include both alteration of the gene expression and modulation of the phosphorylation state of important targets of the signal transduction pathways.A pro-oxidant activity of olive oil phenols at high concentrations has been hypothesized. |
| Handle: | http://hdl.handle.net/11391/38024 |
| ISBN: | 9780123744203 |
| Appare nelle tipologie: | 2.1 Contributo in volume (Capitolo o Saggio) |
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