A review discusses the importance of heterocycles in the discovery of new drugs. The development of synthetic methodologies for the preparation of 2-substituted aziridinyl derivs. and their application to the synthesis of compds. of biol. interest is discussed, and the synthesis of new PARP inhibitors, neuroprotective agents endowed with enhanced potency and selectivity is described.
Heterocycles as Companions on Route to Drug Discovery
PELLICCIARI, Roberto;CAMAIONI, Emidio;MARINOZZI, Maura
2002
Abstract
A review discusses the importance of heterocycles in the discovery of new drugs. The development of synthetic methodologies for the preparation of 2-substituted aziridinyl derivs. and their application to the synthesis of compds. of biol. interest is discussed, and the synthesis of new PARP inhibitors, neuroprotective agents endowed with enhanced potency and selectivity is described.File in questo prodotto:
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