IRIS - Res&Arch Institutional Research Information System - Research & Archive

GRIGNANI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 1.951
EU - Europa 1.889
AS - Asia 260
OC - Oceania 3
Continente sconosciuto - Info sul continente non disponibili 1
Totale 4.104
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Nazione #
US - Stati Uniti d'America 1.940
UA - Ucraina 507
IE - Irlanda 357
SE - Svezia 350
IT - Italia 257
FI - Finlandia 117
DE - Germania 94
HK - Hong Kong 92
VN - Vietnam 82
RU - Federazione Russa 58
GB - Regno Unito 51
CN - Cina 48
FR - Francia 22
CH - Svizzera 17
RO - Romania 17
BE - Belgio 16
TR - Turchia 15
CA - Canada 11
AT - Austria 10
LB - Libano 8
UZ - Uzbekistan 8
GR - Grecia 7
NL - Olanda 3
PL - Polonia 3
SG - Singapore 3
NZ - Nuova Zelanda 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AU - Australia 1
BN - Brunei Darussalam 1
HU - Ungheria 1
IN - India 1
IR - Iran 1
LT - Lituania 1
NO - Norvegia 1
SA - Arabia Saudita 1
Totale 4.104
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Città #
Chandler 460
Dublin 357
Jacksonville 252
San Mateo 169
Altamura 117
Ann Arbor 93
Hong Kong 92
Medford 89
Princeton 89
Dong Ket 82
Lawrence 79
Perugia 75
Wilmington 74
Des Moines 47
Andover 44
Beijing 42
Helsinki 32
New York 32
Ashburn 20
Woodbridge 20
Bucharest 17
Brussels 16
Norwalk 16
Izmir 14
Saint Petersburg 14
Los Angeles 11
San Paolo di Civitate 11
Ottawa 10
Boardman 9
Falls Church 8
Rome 8
Auburn Hills 6
Shanghai 5
Bologna 4
Città Di Castello 4
Lausanne 4
Moscow 4
Houston 3
Redwood City 3
San Diego 3
Seattle 3
Simi Valley 3
Alghero 2
Den Haag 2
Milan 2
Philadelphia 2
Redmond 2
Saxony 2
Terni 2
Ardabil 1
Bandar Seri Begawan 1
Beauharnois 1
Bedford 1
Birmingham 1
Camparada 1
Charlotte 1
Chicago 1
Clearwater 1
Compton 1
Dallas 1
Dewsbury 1
Edinburgh 1
Ellon 1
Foligno 1
Gulfport 1
Guttingen 1
Hialeah 1
Jonesboro 1
Kiev 1
Kunming 1
Las Vegas 1
Modena 1
Mumbai 1
New Orleans 1
Oslo 1
Padova 1
Parma 1
Riyadh 1
Salida 1
Sterling 1
Sydney 1
Szeged 1
Taranaki 1
Tasman 1
Vilnius 1
Totale 2.491
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Nome #
Effect of the acute promyelocytic leukemia PML/RAR alpha protein on differentiation and survival of myeloid precursors. 89
Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells. 89
Formation of PML/RAR alpha high molecular weight nuclear complexes through the PML coiled-coil region is essential for the PML/RAR alpha-mediated retinoic acid response 81
MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation 81
Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. 75
Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism 74
Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells. 71
Expression and role of PML gene in normal adult hematopoiesis: functional interaction between PML and Rb proteins in erythropoiesis. 70
Down regulation of LFA-I adhesion receptor by the c-myc oncogene in human B-lymphoblastoid cells 70
Eicosapentaenoic acid demethylates a single CpG that mediates expression of tumor suppressor CCAAT/enhancer-binding protein delta in U937 leukemia cells. 68
Human CD4 lymphocytes recognize a peptide representing the fusion region of the hybrid protein PML/RARa present in acute promyelocytic leukemia cells. 66
Oncoproteins, heterochromatin silencing and microRNAs: a new link for leukemogenesis. 63
Myelomonocytic-associated antigens in a case of genotypically, phenotypically and functionally B-cell lymphoma. 63
The acute promyelocytic leukaemia specific PML/RARa fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. 63
Cooperation between RING+B1-B2 and coiled-coil domains of PML is necesary for its effects on cell growth 62
Molecular Pathogenesis of Acute Promyelocytic Leukaemia. 60
Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. 60
Acute Promyelocytic Leukemia: from genetics to treatment. 59
A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis 58
Negative autoregulation of c-myc expression is inactivated in trasformed cells 57
Acute promyelocytic leukemia cells resistant to retinoic acid show further perturbation of the RARa signal transduction system. 57
Btg2 Enhances Retinoic Acid Induced Differentiation By Modulating Histone H4 Methylation And Acetylation 57
Opposite effects of Acute promyelocytic leukemia PML/RARa and PLZF/RARa fusion proteins on retinoic acid signalling. 56
Atypical response to all-trans retinoic acid in a der(5)t(5;17) acute promyelocytic leukemia 56
C-MYB activation and the pathogenesis of ovarian cancer. 56
The acute promyelocytic leukemia-specific PML/RAR alpha fusion protein reduces the frequency of commitment to apoptosis upon growth factor deprivation of GM-CSF-dependent myeloid cells. 54
PML is required for telomere stability in non-neoplastic human cells 54
Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression. 53
Epigenetic role of miRNAs in normal and leukemic hematopoiesis. 53
N-(4-Hydroxyphenyl) retinamide Induces Apoptosis of Malignant Hemopoietic Cell Lines Including Those Unresponsive to Retinoic Acid. 53
Cellular localization and tissue distribution of PML proteins as defined by a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product. Preferential expression in postmitotic cells. 52
Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane 52
A novel trasforming protein with a SH2 domain is implicated in mitogenic signal transduction. 51
Prognostic Role of Circulating miRNAs in Early-Stage Non-Small Cell Lung Cancer 51
Histone deacetylase recruitment by RARa fusion proteins in promyelocytic leukemia 51
Caspases mediate RA-induced degradation of acute promyelocytic leukemia PML/RARa fusion protein 50
In vitro response to all trans Retinoic acid of acute promyelocytic leukemia with non reciprocal PML/RARa or RAR/PML fusion genes. 50
Blocking the APRIL circuit enhances acute myeloid leukemia cell chemosensitivity. 50
Effects on differentiation by the promyelocytic leukemia PML/RARa protein depend on the fusion of the PML protein-dimerization and RARa DNA binding domains. 49
Characterization of the PML/RARa chimeric product of the acute promyelocytic leukemia specific t(15;17) translocation. 49
Identification of DNA rearrangements at the RAR-a locus in all patients with acute promyelocytic leukemia (APL) and mapping of APL breakpoints within the RAR-a second intron 49
Vaccini antitumorali: novità biologiche e cliniche. 47
Pathogenetic Relevance Of The Acute Promyelocytic Leukemia-Specific PML/RARa Fusion Protein 47
A pool of peptides extracted from wheat bud chromatin inhibits tumor cell growth by causing defective DNA synthesis 47
Terminal megakaryocytic differentiationof TF-1 cells is induced by phorbol esters and thrombopoietin and is blocked by expression of PML/RARa fusion protein. 46
Expression of SMRTbeta promotes ligand-induced activation of mutated and wild-type retinoid receptors. 46
Natural killer cell-mediated lysis of autologous cells modified by gene therapy 46
The molecular genetics of acute promyelocytic leukemia 46
Biological and Clinical developments in cancer vaccines 45
Targeting the KRAS variant for treatment of non-small cell lung cancer: Potential therapeutic applications 45
DeltaN-p73 is a transcriptional target of the PML/RARalpha oncogene in myeloid differentiation. 45
Efficient infection and selection of hematopoietic progenitors by a novel GFP based retroviral vector 44
Cell death induction by the acute promyelocytic leukemia specific PML/RARa fusion protein. 44
Infrequent alteration of the RARa gene in acute myelogenous leukemias, retinoic acid-resistant acute promyelocytic leukemias, myelodysplastic syndromes and cell lines. 43
Retinoid -induced differentiation of acute promyelocytic leukemia involves PML/RARa-mediated increase of type II transglutaminase. 43
High frequency of clonal immunoglobulin or T cell receptor gene rearrangements in acute myelogenous leukemia expressing terminal deoxyribonucleotidyltransferase. 43
Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors. 42
Promyelocytic leukemia specific PML-retinoic acid receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells. 40
PML/RARa fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype 40
Occurrence of Resistance to Retinoic Acid in the Acute Promyelocytic Leukemia Cell Line NB4 Is Associated With Altered Expression of the PMLRARa Protein. 39
Impaired differentiation of U937 cell mutants expressing the PML/RARa fusion protein is unblocked by retinoic acid. 39
Gene regulation in normal and leukaemic progenitor/stem cells. 39
The localization of the HRX proteinto specific nuclear subomains is altered by fusion with its eps15 translocation partner 39
Growth and Tumor Promoting Effects of Deregulated Bcl-2 in Human B Lymphoblastoid Cells 38
Thyroid function tests in patients undergoing maintenance dialysis: characterization of the 'low-T4 syndrome' in subjects on regular hemodialysis and continuous ambulatory peritoneal dialysis. 38
In vitro transcription and translation inhibition by anti-PML/RARa and PML peptide nucleic acid (PNA). 37
The PML/RARa fusion protein inhibits TNFa-induced apoptosis in U937 cells and in acute promyelocytic leukemia blasts. 37
Structure and origin of the acute promyelocityc leukaemia MYL/RARa cDNA and characterization of its retinoid binding and transactivation properties 36
The promyelocytic leukemia (PML) gene product is a cellular target of the adenovirus E1A protein and functionally interacts with the retinoblastoma protein. 36
Molecular genetics of the t(15;17) of acute promyelocytic leukemia (APPL). 36
Molecular Genetics Of The T(15;17) Of Acute Promyelocytic Leukemia 36
Pathogenetic role of the PML1RAR alpha fusion protein in acute promyelocytic leukemia. 35
Transcriptional targeting by microRNA-Polycomb complexes: a novel route in cell fate determination 34
Molecular biology of acute promyelocytic leukemia 34
MiRNAs and resistance to EGFRâ€"TKIs in EGFR-mutant non-small cell lung cancer: Beyond 'traditional mechanisms' of resistance 33
Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor status. 32
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1 32
The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies. 32
Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. 31
The molecular genetics of acute promyelocytic leukemia. 30
Genetics of APL and the molecular basis of retinoic acid treatment. 30
Molecular biology of lymphoid malignancies. 29
Mechanism of negative feed-back regulation of c-myc gene expression in B-cells and its inactivation in tumor cells. 28
Low brachial artery flow-mediated dilation predicts worse prognosis in hospitalized patients with covid-19 28
The acute promyelocytic leukemia PML/RARa protein affects differentiation and survival of myeloid precursor cells 24
Systemic lupus erythematosus following total body irradiation for malignant lymphoma. 23
Natural killer cell-mediated lysis of autologous cells modified by gene therapy 22
RARs and microRNAs 22
Molecular mechanisms underlying eicosapentaenoic acid inhibition of HDAC1 and DNMT expression and activity in carcinoma cells 21
PCSK9 and cancer: Rethinking the link 19
Genetic lesions disrupting calreticulin 3'-untranslated region in JAK2 mutation-negative polycythemia vera 8
Totale 4.278
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Categoria #
all - tutte 15.031
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 15.031
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201923 0 0 0 0 0 0 0 0 0 0 22 1
2019/2020440 8 2 67 6 64 3 80 2 88 57 6 57
2020/2021892 7 73 37 77 234 63 72 1 110 37 83 98
2021/2022739 21 109 30 64 30 6 8 222 12 21 90 126
2022/20231.447 97 283 25 108 134 200 0 58 480 4 45 13
2023/2024289 35 60 23 8 15 9 83 6 44 6 0 0
Totale 4.278