Modeling the Spontaneous Reaction of Mammalian Cells to External Stimuli

We argue that the potential benets of developing high-fidelity models of biological communication systems has enormous potential in terms of enhancing the understanding of biological systems and that such understanding is a major step towards detection and treatment of disease. By focusing on lysosomal enzyme response to stimuli, we demonstrate that the understanding of the protocols governing cellular communications is far from complete. We discuss some major challenges and outline promising approaches to reaching the next level.