Our research program is committed to the optimization of synthetic procedures for the production of fine chemicals by employing eco-friendly reaction protocols using water[1] or solvent-free conditions (SolFC).[2] We have found that combining the use of polymer-supported organocatalysts and SolFC is an attractive approach to overcome the significant loss in terms of efficiency of a supported catalyst compared to that of its non-supported counterpart. Under SolFC the higher intimacy of the reactants results in a higher reactivity and the choice of the solid polymer used as support may reset the problems related to swelling process.[2e] Our approach is mainly based on the preparation of tailor-made solid supports specifically designed to achieve the best efficiency for a desired catalytic system in water or under SolFC. Recently, we have planned to realize novel synthetic procedures for the preparation of fine chemicals by setting cyclic continuous-flow reactors able to allow a) an optimal intimacy between the reactants and the catalyst without mechanical stirring, b) the recovery of the product with a negligible amount of organic solvent, and c) to minimize waste production.[2a-d] Some examples from our laboratory will be presented in this communication.
Innovative synthetic tools for a sustainable production of fine chemicals
VACCARO, Luigi
2012
Abstract
Our research program is committed to the optimization of synthetic procedures for the production of fine chemicals by employing eco-friendly reaction protocols using water[1] or solvent-free conditions (SolFC).[2] We have found that combining the use of polymer-supported organocatalysts and SolFC is an attractive approach to overcome the significant loss in terms of efficiency of a supported catalyst compared to that of its non-supported counterpart. Under SolFC the higher intimacy of the reactants results in a higher reactivity and the choice of the solid polymer used as support may reset the problems related to swelling process.[2e] Our approach is mainly based on the preparation of tailor-made solid supports specifically designed to achieve the best efficiency for a desired catalytic system in water or under SolFC. Recently, we have planned to realize novel synthetic procedures for the preparation of fine chemicals by setting cyclic continuous-flow reactors able to allow a) an optimal intimacy between the reactants and the catalyst without mechanical stirring, b) the recovery of the product with a negligible amount of organic solvent, and c) to minimize waste production.[2a-d] Some examples from our laboratory will be presented in this communication.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
