Rat brain S-100 (S-100b) and ox brain S-100a0, S-100a and S-100b have been tested for their ability to control the assembly and disassembly of brain microtubule proteins in the presence of either Ca2+ or Zn2+, in vitro. In the presence of Ca2+, single S-100 isoforms have similar, if not identical, effects, i.e. they inhibit assembly and promote disassembly. In the presence of Zn2+ from 0.1 to 1 mM (free concentration), rat S-100 and ox S-100a and S-100b inhibit assembly, while S-100a0 is without effect. These data are briefly discussed in relation to the cellular localization of single S-100 isoforms in the brain.

S-100 proteins and microtubules: analysis of the effects of rat brain S-100 (S-100b) and ox brain S-l00ao, S-l00a and S-l00b on microtubule assembly-disassembly

DONATO, Rosario Francesco;
1985

Abstract

Rat brain S-100 (S-100b) and ox brain S-100a0, S-100a and S-100b have been tested for their ability to control the assembly and disassembly of brain microtubule proteins in the presence of either Ca2+ or Zn2+, in vitro. In the presence of Ca2+, single S-100 isoforms have similar, if not identical, effects, i.e. they inhibit assembly and promote disassembly. In the presence of Zn2+ from 0.1 to 1 mM (free concentration), rat S-100 and ox S-100a and S-100b inhibit assembly, while S-100a0 is without effect. These data are briefly discussed in relation to the cellular localization of single S-100 isoforms in the brain.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11391/102235
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