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EnglishLiver microsomes were enriched in liposomal acidic lipids by Ca2+ -dependent fusion of liposomes at pH 7.0. The extent of fusion was monitored by the transfer of radioactive cholesteryl oleate. The enrichment of membranes in phosphatidylserine inhibited ethanolamine base-exchange, whereas the fusion with phosphatidylinositol inhibited both ethanolamine and serine base-exchange reactions. In contrast, these two phospholipids had scarce effects on choline base-exchange. Phosphatidic acid did not suppress any of the three base-exchange activities. Possible functional implications are discussed.
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| Titolo: | Regulation of liver base exchange activity by acidic phospholipids |
| Autori: | |
| Data di pubblicazione: | 1991 |
| Rivista: | |
| Abstract: | Liver microsomes were enriched in liposomal acidic lipids by Ca2+ -dependent fusion of liposomes ...at pH 7.0. The extent of fusion was monitored by the transfer of radioactive cholesteryl oleate. The enrichment of membranes in phosphatidylserine inhibited ethanolamine base-exchange, whereas the fusion with phosphatidylinositol inhibited both ethanolamine and serine base-exchange reactions. In contrast, these two phospholipids had scarce effects on choline base-exchange. Phosphatidic acid did not suppress any of the three base-exchange activities. Possible functional implications are discussed. |
| Handle: | http://hdl.handle.net/11391/102651 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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