Epidemiological studies may greatly benefit our understanding of the interactions between environment and genetic factors related to the pathogenesis of IDDM. Aim of our study was to evaluate the incidence of IDDM in the 0-29 yrs age-group in Umbria, a region of Central Italy, during the period 1993-1995. A regional registry was established to collect blood samples and clinical data on incident cases of IDDM from 17 hospitals or departments of the Umbria region (primary data source). A secondary and independent data source used the computerised filing system for insulin prescriptions of the Umbria region. During the years 1993-1995, the incidence of IDDM in the 0-29 yrs age-group in Umbria resulted 9.2/100,000/yr. Age-standardised incidence rate in the 0-14 yrs age-group was 9.0/100,000/yr, and in the 15-29 yrs age-group 9.2/100,000/yr. Incidence of IDDM in 0-4 yr-old children was 10.2/100,000/yr in 1993-1995 and 11.7/100,000/yr during the period 1990-1995. In the 15-29 yrs age-group, age-standardised incidence rate of IDDM was significantly higher in males (12.7/100,000/yr) than in females (5.2/100,000/yr) (p = 0.009). A low incidence of IDDM was observed during the summer months [July to September, n = 10/76 (13%) cases] as compared to the other seasons [n = 21/76 (28%) to 23/76 (30%) cases]. The results of our study show that 1) age-standardised incidence of IDDM in Umbria was similar to that observed in other regions of mainland Italy, 2) the incidence of IDDM in the 0-4 yrs age-group, as observed during the period 1990-1995, was significantly higher in Umbria than in neighbouring regions, as observed during 1989-1993, and 3) a significantly higher incidence of IDDM was observed among males than among females in the 15-29 yrs age-group.
Incidence of IDDM in the 0-29 years age-group in Umbria, Italy
FALORNI, Alberto;
1997
Abstract
Epidemiological studies may greatly benefit our understanding of the interactions between environment and genetic factors related to the pathogenesis of IDDM. Aim of our study was to evaluate the incidence of IDDM in the 0-29 yrs age-group in Umbria, a region of Central Italy, during the period 1993-1995. A regional registry was established to collect blood samples and clinical data on incident cases of IDDM from 17 hospitals or departments of the Umbria region (primary data source). A secondary and independent data source used the computerised filing system for insulin prescriptions of the Umbria region. During the years 1993-1995, the incidence of IDDM in the 0-29 yrs age-group in Umbria resulted 9.2/100,000/yr. Age-standardised incidence rate in the 0-14 yrs age-group was 9.0/100,000/yr, and in the 15-29 yrs age-group 9.2/100,000/yr. Incidence of IDDM in 0-4 yr-old children was 10.2/100,000/yr in 1993-1995 and 11.7/100,000/yr during the period 1990-1995. In the 15-29 yrs age-group, age-standardised incidence rate of IDDM was significantly higher in males (12.7/100,000/yr) than in females (5.2/100,000/yr) (p = 0.009). A low incidence of IDDM was observed during the summer months [July to September, n = 10/76 (13%) cases] as compared to the other seasons [n = 21/76 (28%) to 23/76 (30%) cases]. The results of our study show that 1) age-standardised incidence of IDDM in Umbria was similar to that observed in other regions of mainland Italy, 2) the incidence of IDDM in the 0-4 yrs age-group, as observed during the period 1990-1995, was significantly higher in Umbria than in neighbouring regions, as observed during 1989-1993, and 3) a significantly higher incidence of IDDM was observed among males than among females in the 15-29 yrs age-group.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
