Our research program is committed to the optimization of synthetic procedures by employing eco-friendly reaction protocols, including the use of water and solvent-free conditions (SolFC). We have found that combining the use of polymer-supported organocatalysts and SolFC is an attractive approach to overcome the significant loss in terms of efficiency of a supported catalyst compared to that of its non-supported counterpart. Under SolFC the higher intimacy of the reactants results in a higher reactivity and the choice of the solid polymer used as support may reset the problems related to swelling process. Recently, we have planned to realize cyclic continuous-flow reactors able to improve SolFC reactions allowing a) the optimal intimacy between the reactants and the catalyst without mechanical stirring, and b) the recovery of the product with a negligible amount of organic solvent.
SOLVENT-FREE CONTINUOUS-FLOW PROTOCOLS FOR DEVELOPING A GREEN ORGANIC SYNTHESIS
LANARI, DANIELA;PIZZO, Ferdinando;VACCARO, Luigi
2010
Abstract
Our research program is committed to the optimization of synthetic procedures by employing eco-friendly reaction protocols, including the use of water and solvent-free conditions (SolFC). We have found that combining the use of polymer-supported organocatalysts and SolFC is an attractive approach to overcome the significant loss in terms of efficiency of a supported catalyst compared to that of its non-supported counterpart. Under SolFC the higher intimacy of the reactants results in a higher reactivity and the choice of the solid polymer used as support may reset the problems related to swelling process. Recently, we have planned to realize cyclic continuous-flow reactors able to improve SolFC reactions allowing a) the optimal intimacy between the reactants and the catalyst without mechanical stirring, and b) the recovery of the product with a negligible amount of organic solvent.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
