In this study, we synthesized some natural and semisynthetic prenyloxyphenylpropanoids (e.g., comarins and cinnamic acid derivatives) and we assessed their in vitro inhibitory activity against farnesyl transferase (FTase) and geranylgeranyl transferase 1 (GGTase 1). No compound was an effective inhibitor of FTase, while farnesyloxycinnamic acids were shown to selectively inhibit GGTase 1 with IC50 values ranging from 28 to 39 mu M.
“Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I”
CURINI, Massimo;
2007
Abstract
In this study, we synthesized some natural and semisynthetic prenyloxyphenylpropanoids (e.g., comarins and cinnamic acid derivatives) and we assessed their in vitro inhibitory activity against farnesyl transferase (FTase) and geranylgeranyl transferase 1 (GGTase 1). No compound was an effective inhibitor of FTase, while farnesyloxycinnamic acids were shown to selectively inhibit GGTase 1 with IC50 values ranging from 28 to 39 mu M.File in questo prodotto:
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