Plant virus nanoparticles are showing great potential as delivery system for diagnostics and therapeutics. The aim of the study was to evaluate the toxicity and teratogenicity of Potato Virus X (PVX) and Tomato Bushy Stunt Virus (TBSV) by direct yolk sac injection in early chick embryos. Even though additional results and tests in other animal models are mandatory to have conclusive opinion on the safety of these NPs, the reported results evidenced their safety in chick embryo model.
In vivo toxicity and teratogenicity evaluation of plant virus nanoparticles
BLASI, PAOLO;BARBERINI, Lanfranco;SCHOUBBEN, Aurelie Marie Madeleine;CIROTTO, Carlo;
2013
Abstract
Plant virus nanoparticles are showing great potential as delivery system for diagnostics and therapeutics. The aim of the study was to evaluate the toxicity and teratogenicity of Potato Virus X (PVX) and Tomato Bushy Stunt Virus (TBSV) by direct yolk sac injection in early chick embryos. Even though additional results and tests in other animal models are mandatory to have conclusive opinion on the safety of these NPs, the reported results evidenced their safety in chick embryo model.File in questo prodotto:
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