Abstract: The efficacy and tolerability of taurine (3 g daily) in the treatment of intermittent claudication were evaluated in a double-blind placebo-controlled study in 40 patients. Before therapy and after 3 and 6 months, besides standard treadmill exercise walking times, ankle/arm pressure ratios, plethysmographic peak flow values, transcutaneous oxygen pressure (TcPO2) was also monitored on the dorsum of the foot in basal conditions together with the half-recovery times after an induced ischemia. Taurine was more beneficial than placebo in lengthening the pain-free and total walking times and significantly shortened TcPO2 half-recovery time. These results suggest that taurine not only improves performance in patients with intermittent claudication but also increases oxygenation in the ischemic limbs
TAURINE THERAPY FOR INTERMITTENT CLAUDICATION - RESULTS OF A CONTROLLED-STUDY
PASQUALINI, Leonella;VAUDO, Gaetano;CIUFFETTI, Giovanni;MANNARINO, Elmo
1993
Abstract
Abstract: The efficacy and tolerability of taurine (3 g daily) in the treatment of intermittent claudication were evaluated in a double-blind placebo-controlled study in 40 patients. Before therapy and after 3 and 6 months, besides standard treadmill exercise walking times, ankle/arm pressure ratios, plethysmographic peak flow values, transcutaneous oxygen pressure (TcPO2) was also monitored on the dorsum of the foot in basal conditions together with the half-recovery times after an induced ischemia. Taurine was more beneficial than placebo in lengthening the pain-free and total walking times and significantly shortened TcPO2 half-recovery time. These results suggest that taurine not only improves performance in patients with intermittent claudication but also increases oxygenation in the ischemic limbsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
