The kinetics of hydrolysis of indomethacin and related compounds was studied in an alkaline medium at 25°C in the presence of anionic (sodium dodecyl sulfate) and cationic (hexadecyltrimethylam-monium bromide) surfactants. The rate-surfactant profiles for rate inhibition in the presence of sodium dodecyl sulfate and rate enhancement in the presence of hexadecyltrimethylammonium bromide were analyzed in terms of the current theory of micellar effects.
Micellar Effects on the Basic Hydrolysis of Indomethacin and Related Compounds
GERMANI, Raimondo;SAVELLI, Gianfranco
1985
Abstract
The kinetics of hydrolysis of indomethacin and related compounds was studied in an alkaline medium at 25°C in the presence of anionic (sodium dodecyl sulfate) and cationic (hexadecyltrimethylam-monium bromide) surfactants. The rate-surfactant profiles for rate inhibition in the presence of sodium dodecyl sulfate and rate enhancement in the presence of hexadecyltrimethylammonium bromide were analyzed in terms of the current theory of micellar effects.File in questo prodotto:
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