A new 2-steps synthesis of 2′-epi-Taxol starting from natural Taxol• is described. The approach is centred on the formation of oxazoline on the side chain with concomitant inversion of the C-2′ followed by acid hydrolysis.
A High Yield Semisynthetic Approach to 2’-epi-Taxol
CURINI, Massimo;MARCOTULLIO, Maria Carla;ROSATI, Ornelio
1996
Abstract
A new 2-steps synthesis of 2′-epi-Taxol starting from natural Taxol• is described. The approach is centred on the formation of oxazoline on the side chain with concomitant inversion of the C-2′ followed by acid hydrolysis.File in questo prodotto:
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