A novel, simple, and flexible approach to alpha,alpha-disubstituted gamma-lactams via a domino Michael addition/cyclization process involving the phenyl vinyl selenone and beta-ketoamides, malonylamides or beta-cyanoamides is reported. The reactions proceed in good to excellent yields under mild reaction conditions.
Synthesis of gamma- Lactams via a Domino Michael Addition/Cyclization Reaction of Vinyl Selenone with Substituted Amides
STERNATIVO, Silvia;BATTISTELLI, BENEDETTA;BAGNOLI, Luana;SANTI, Claudio;TESTAFERRI, Lorenzo;MARINI, Francesca
2013
Abstract
A novel, simple, and flexible approach to alpha,alpha-disubstituted gamma-lactams via a domino Michael addition/cyclization process involving the phenyl vinyl selenone and beta-ketoamides, malonylamides or beta-cyanoamides is reported. The reactions proceed in good to excellent yields under mild reaction conditions.File in questo prodotto:
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