By combining the results of kinetic measurements with DFT calculations we provide a clear-cut evidence of the merging between the E2 and E1cb reaction mechanisms for a large series of leaving groups. Our results solve a long-debated issue in chemical reactivity with profound implications both from a fundamental and biological point of view, thus paving the way to further investigations with different substrates.
Merging of E2 and E1cb reaction mechanisms: a combined theoretical and experimental study
MOSCONI, EDOARDO;F. De Angelis;BELPASSI, LEONARDO;TARANTELLI, Francesco;ALUNNI, Sergio
2009
Abstract
By combining the results of kinetic measurements with DFT calculations we provide a clear-cut evidence of the merging between the E2 and E1cb reaction mechanisms for a large series of leaving groups. Our results solve a long-debated issue in chemical reactivity with profound implications both from a fundamental and biological point of view, thus paving the way to further investigations with different substrates.File in questo prodotto:
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