A dynamic coating of the RP-18 carbon chain layers with the new chiral selector (S)-(-)-α,α-di(2-naphthyl)-2-pyrrolidinemethanol allowed the formation of a mixed chiral stationary phase that has been used in the separation of a selected set of amino acid racemates. Both a representative model and classification structure-property relationship studies have been performed in order to study the contribution of hydrophobic, bulky and electron-donating groups in the side chain of the chiral selector to the mechanism of chiral recognition

(S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidine Methanol, a Useful Tool to Study the Recognition Mechanism in Chiral Ligand-Exchange Chromatography (CLEC)

NATALINI, Benedetto;SARDELLA, Roccaldo;MACCHIARULO, Antonio;PELLICCIARI, Roberto
2007

Abstract

A dynamic coating of the RP-18 carbon chain layers with the new chiral selector (S)-(-)-α,α-di(2-naphthyl)-2-pyrrolidinemethanol allowed the formation of a mixed chiral stationary phase that has been used in the separation of a selected set of amino acid racemates. Both a representative model and classification structure-property relationship studies have been performed in order to study the contribution of hydrophobic, bulky and electron-donating groups in the side chain of the chiral selector to the mechanism of chiral recognition
2007
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/116941
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