Mucoadhesive tablets using different mixture of cellulose and polyacrylic derivatives were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling studies, ex vivo and in vivo mucoadhesive time, ex vivo mucoadhesion force, in vitro and in vivo release. The best mucoadhesive performance and the best in vitro drug release profile were achieved by using hydroxyethyl cellulose (HEC) and carbomer 940 2:2 ratio. The chosen device, containing 20 mg of metronidazole, performed 12 hours drug sustained release with buccal concentrations always higher than its MIC.
Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal diseases
PERIOLI, Luana;AMBROGI, Valeria;GIOVAGNOLI, Stefano;RICCI, Maurizio;BLASI, PAOLO;ROSSI, Carlo
2004
Abstract
Mucoadhesive tablets using different mixture of cellulose and polyacrylic derivatives were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling studies, ex vivo and in vivo mucoadhesive time, ex vivo mucoadhesion force, in vitro and in vivo release. The best mucoadhesive performance and the best in vitro drug release profile were achieved by using hydroxyethyl cellulose (HEC) and carbomer 940 2:2 ratio. The chosen device, containing 20 mg of metronidazole, performed 12 hours drug sustained release with buccal concentrations always higher than its MIC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
