The enantioselective substitution of α-cyanoacetates on imidoyl chlorides under phase-transfer catalytic conditions is presented; a simple quinidine-derived phase-transfer catalyst gives access to the products, highly substituted ketimines, in generally good yields and up to 90% ee.
Enantioselective organocatalytic substitution of α-cyanoacetates on imidoyl chlorides – synthesis of optically active ketimines
SANTORO, STEFANO;
2007
Abstract
The enantioselective substitution of α-cyanoacetates on imidoyl chlorides under phase-transfer catalytic conditions is presented; a simple quinidine-derived phase-transfer catalyst gives access to the products, highly substituted ketimines, in generally good yields and up to 90% ee.File in questo prodotto:
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