Lapatinib is able to penetrate brain metastases from HER2-positive breast cancer. We assessed lapatinib concentration in cerebrospinal fluid (CSF) of two patients with HER2-positive metastatic breast cancer and brain metastases, and we found low levels of the drug in CSF of both patients. Lapatinib concentration in CSF may not be a reliable surrogate of its distribution in brain metastases.
Lapatinib concentration in cerebrospinal fluid in two patients with HER2-positive metastatic breast cancer and brain metastases
FOGLIETTA, JENNIFER;CRINO', Lucio
2014
Abstract
Lapatinib is able to penetrate brain metastases from HER2-positive breast cancer. We assessed lapatinib concentration in cerebrospinal fluid (CSF) of two patients with HER2-positive metastatic breast cancer and brain metastases, and we found low levels of the drug in CSF of both patients. Lapatinib concentration in CSF may not be a reliable surrogate of its distribution in brain metastases.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
