The liver is one of the most important organs responsible for the elimination of xenobiotics and there is considerable regulatory pressure to characterize the in vivo pharmacokinetic (PK) changes in subjects with liver disease (LD). Despite this, predictions of the potential effect of LD on the PK of compounds present several limitations.
Some considerations on the predictions of pharmacokinetic alterations in subjects with liver disease
GORACCI, LAURA;CRUCIANI, Gabriele;
2014
Abstract
The liver is one of the most important organs responsible for the elimination of xenobiotics and there is considerable regulatory pressure to characterize the in vivo pharmacokinetic (PK) changes in subjects with liver disease (LD). Despite this, predictions of the potential effect of LD on the PK of compounds present several limitations.File in questo prodotto:
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