Aggressive cancer is often characterized by high expression of gelatinases, namely matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). These enzymes play a pivotal role in tumor invasion and metastasis by degradation of extracellular matrix (ECM) leading to cancer spread both to contiguous tissues and distant organs. Feline injection-site sarcoma (FISS) is an aggressive subcutaneous tumor that develops a variable period after vaccination. Aim of this study was to investigate the expression of MMP-2and MMP-9 in FISS and assess their possible role as prognostic markers to predict tumor recurrence ormetastasis after excisional surgery.
THE EXPRESSION OF MATRIX METALLOPROTEINASE 2 (MMP-2) AND 9 (MMP-9) AND THEIR POSSIBLE PROGNOSTIC ROLE IN FELINE INJECTION-SITE SARCOMAS (FISS)
PORCELLATO, ILARIA;BRACHELENTE, CHIARA;SFORNA, Monica;LEPRI, Elvio;REGINATO, ALICE;MECHELLI, Luca
2014
Abstract
Aggressive cancer is often characterized by high expression of gelatinases, namely matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). These enzymes play a pivotal role in tumor invasion and metastasis by degradation of extracellular matrix (ECM) leading to cancer spread both to contiguous tissues and distant organs. Feline injection-site sarcoma (FISS) is an aggressive subcutaneous tumor that develops a variable period after vaccination. Aim of this study was to investigate the expression of MMP-2and MMP-9 in FISS and assess their possible role as prognostic markers to predict tumor recurrence ormetastasis after excisional surgery.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
