Porcine Sertoli cells (pSCs) have been employed for cell therapy in pre-clinical studies for several chronic/immune diseases as they deliver molecules associated with trophic and anti-inflammatory effects. To be employed for human xenografts, pSCs products need to comply with safety and stability. To fulfill such requirements, we employed a microencapsulation technology to increase pre-transplant storage stability of specific pathogen-free pSCs (SPF-pSCs) and evaluated the in vivo long-term viability and safety of grafts.

Long-term stability, functional competence, and safety of microencapsulated specific pathogen-free neonatal porcine Sertoli cells: a potential product for cell transplant therapy

LUCA, Giovanni;MANCUSO, FRANCESCA;CALVITTI, Mario;ARATO, IVA;BUFALARI, Antonello;DE MONTE, VALENTINA;NASTRUZZI, Claudio;FALLARINO, Francesca;LILLI, Cinzia;BELLUCCI, Catia;BARONI, Tiziano;AGLIETTI, Maria Chiara;GIOVAGNOLI, Stefano;BODO, Maria;CALAFIORE, Riccardo
2015

Abstract

Porcine Sertoli cells (pSCs) have been employed for cell therapy in pre-clinical studies for several chronic/immune diseases as they deliver molecules associated with trophic and anti-inflammatory effects. To be employed for human xenografts, pSCs products need to comply with safety and stability. To fulfill such requirements, we employed a microencapsulation technology to increase pre-transplant storage stability of specific pathogen-free pSCs (SPF-pSCs) and evaluated the in vivo long-term viability and safety of grafts.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1351293
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